Welcome to a journey through the heart of Appalachia, where history, adventure, and culture intertwine. This 7-day itinerary will take you through Lewisburg, West Virginia, Knoxville, Tennessee, and Asheville, North Carolina. Each city offers a unique blend of natural beauty, vibrant arts scenes, and culinary delights that promise to captivate your senses.

Lewisburg, known for its charming downtown and rich history, is a gateway to the stunning landscapes of West Virginia. Knoxville, a city that harmoniously blends Southern hospitality with a lively arts scene, offers a plethora of activities for every traveler. Asheville, nestled in the Blue Ridge Mountains, is renowned for its eclectic vibe, craft breweries, and the iconic Biltmore Estate.

Prepare for an adventure that includes whitewater rafting, zip-lining, and exploring national parks. Along the way, savor local cuisines, from Appalachian comfort food to innovative Southern dishes. This itinerary is designed to provide a perfect balance of relaxation and excitement, ensuring an unforgettable experience.

Lewisburg, West Virginia

Day 1: Arrival in Lewisburg

Afternoon: Arrive in Lewisburg and check into your accommodation. Consider staying at a cozy VRBO or a comfortable hotel via Hotels.com.

Evening: Stroll through the historic downtown area, exploring local shops and galleries. For dinner, head to The French Goat, a charming bistro offering French-inspired cuisine with a Southern twist.

Day 2: Outdoor Adventures

Embark on a thrilling whitewater rafting experience in the New River Gorge. Choose from options like the National Park Whitewater Rafting or the Lower New River Whitewater Rafting Trip.

After a day of adventure, enjoy a hearty meal at The Livery Tavern, known for its farm-to-table dishes and historic ambiance.

Day 3: Explore Lewisburg

Morning: Start your day with a visit to the Greenbrier Valley Theatre, the state’s year-round professional theatre, for a behind-the-scenes tour.

Afternoon: Visit the Lost World Caverns, a fascinating underground wonder. Explore the stunning formations and learn about the cave's history.

Evening: Dine at Stardust Cafe, a local favorite offering organic and locally sourced dishes. Try their famous crab cakes or the vegetarian-friendly portobello sandwich.

Knoxville, Tennessee

Day 4: Travel to Knoxville

Depart Lewisburg in the morning and head to Knoxville, a journey of approximately 4 hours by car. Upon arrival, check into your accommodation via Hotels.com.

Afternoon: Explore Market Square, a vibrant area filled with shops, restaurants, and live music. Grab lunch at Tomato Head, known for its creative pizzas and fresh salads.

Evening: Visit the Sunsphere, an iconic structure from the 1982 World’s Fair, for panoramic views of the city. For dinner, head to Stock & Barrel for gourmet burgers and craft cocktails.

Day 5: Discover Knoxville

Morning: Start your day with a visit to the Knoxville Museum of Art, showcasing regional artists and contemporary works.

Afternoon: Take a leisurely walk through the Ijams Nature Center, a beautiful urban greenspace offering trails, rock formations, and a quarry lake.

Evening: Enjoy a Southern-style dinner at Calhoun’s on the River, offering stunning views of the Tennessee River and a menu featuring BBQ ribs and smoked chicken.

Asheville, North Carolina

Day 6: Travel to Asheville

Depart Knoxville in the morning and travel to Asheville, a scenic drive of about 2 hours. Check into your accommodation via Hotels.com.

Afternoon: Visit the Biltmore Estate, America’s largest home, and explore its stunning gardens and winery.

Evening: Head to downtown Asheville for dinner at Cúrate, a renowned tapas bar offering authentic Spanish cuisine. Don’t miss their signature jamón ibérico.

Day 7: Explore Asheville

Morning: Start your day with a visit to the River Arts District, home to numerous galleries and studios. Enjoy a coffee at Summit Coffee Co., a local favorite.

Afternoon: Take a scenic drive along the Blue Ridge Parkway, stopping at overlooks for breathtaking views of the mountains.

Evening: Conclude your trip with dinner at The Admiral, a hidden gem known for its innovative dishes and cozy atmosphere.

This 7-day itinerary through Lewisburg, Knoxville, and Asheville offers a perfect blend of adventure, culture, and relaxation. From thrilling outdoor activities to exploring vibrant arts scenes and savoring local cuisines, this journey through Appalachia promises unforgettable memories.