7 Days in the Western Mediterranean: A Cruise Itinerary from Barcelona to Marseille, Florence, Rome, and Naples
The Western Mediterranean has drawn sailors and storytellers for millennia—from Phoenician traders and Roman emperors to modern cruisers chasing sun and culture. In a single week you’ll step from Gothic cathedrals to Renaissance galleries, pass medieval ramparts at sea, and taste regional cuisines that define Italy, France, and Spain.
Expect a dynamic mix of city walks, coastal vistas, and iconic museums. Barcelona dazzles with Gaudí’s surreal forms; Marseille brings Provençal flavors and cliff‑top views; Livorno is your gateway to Florence and Pisa; Rome condenses 2,000 years into a day; and Naples pairs Vesuvius‑framed scenery with the world’s most storied pizza.
Practical notes: Prebook timed entries for blockbuster sights (Sagrada Família, Uffizi/Accademia, Vatican Museums, Colosseum). Dress modestly for churches. Watch for pickpockets in busy centers (Las Ramblas, around Trevi). Build a buffer to be back onboard at least 60–90 minutes before all‑aboard. Trains are frequent and affordable—buy tickets in advance where possible.
Barcelona
Barcelona is a mosaic of Roman walls, medieval lanes, and Gaudí’s fantastical architecture. The city’s energy hums from beach boardwalks to boisterous markets like La Boqueria, where counter bars turn seafood into theater.
Top highlights include the still‑rising Sagrada Família, the light‑dappled alleys of the Gothic Quarter, hilltop Montjuïc, and tapas bars where cava flows as easily as conversation.
- Where to stay (pre/post cruise): Browse stays on VRBO Barcelona or hotels on Hotels.com Barcelona. El Born and Eixample are excellent for dining and sights.
- Getting to Barcelona: Search flights on Omio (Flights). If arriving by rail from Spain/France, compare times and prices on Omio (Trains).
Marseille
France’s oldest city has grit and poetry: a dazzling harbor, fortresses guarding the sea, and bouillabaisse born from fishermen’s catch. Sun‑bleached lanes in Le Panier and the vaulted MuCEM bridge past and present.
Climb to Notre‑Dame de la Garde for a panorama of terracotta roofs and the Frioul Islands. At golden hour, Vallon des Auffes feels like a postcard brought to life.
- Where to stay (if extending): See VRBO Marseille or Hotels.com Marseille.
- From port to city: Cruise shuttles and taxis reach Vieux‑Port in ~20–30 minutes. For regional trains, use Omio (Trains).
Livorno (gateway to Florence & Pisa)
Livorno’s canal‑laced “Venezia Nuova” hints at its maritime past, but the great prize inland is Florence—birthplace of the Renaissance—and nearby Pisa with its storied Leaning Tower.
A day here can be art‑packed (Uffizi or Accademia) or split with Pisa for photos on the Campo dei Miracoli.
- Where to stay (if you linger): Find options via VRBO Livorno or Hotels.com Livorno.
- Trains: Livorno–Florence SMN ~1h20 (about €10–€14), Livorno–Pisa Centrale ~20–25 min (about €3–€5). Check schedules on Omio (Trains).
Rome (via Civitavecchia)
Rome reads like a layered archive—emperors and popes, piazzas and palazzi. In one electrifying day you can move from the Sistine Chapel to the Colosseum and still steal a gelato by the Pantheon.
Time tickets and smart routing are essential here; trains from Civitavecchia make DIY days very doable.
- Where to stay (pre/post): Browse VRBO Rome or Hotels.com Rome.
- Train tip: Civitavecchia–Rome (various stations) ~60–75 minutes, about €5–€10. See Omio (Trains).
Naples
Naples brims with charisma—churches layered over ancient tunnels, views to Vesuvius, and pizza certified by tradition. It’s a launchpad to Pompeii, but the city’s coffee bars and pastries merit time of their own.
Expect intense street life, operatic conversations, and some of Italy’s most honest cooking.
- Where to stay (if extending): Explore VRBO Naples or Hotels.com Naples.
- Trains & ferries: Naples–Pompei Scavi ~40 min by Circumvesuviana (~€3–€4). For regional trains and ferries (e.g., Capri), check Omio (Trains) and Omio (Ferries).
Day 1: Barcelona Embarkation
Morning: Travel to Barcelona. If you arrive early, slip into history at Granja Viader (since 1870) for thick hot chocolate and ensaïmada; or grab a flat white at Nomad Coffee. If time allows, stroll El Born’s boutiques toward Santa Maria del Mar.
Afternoon: Transfer to the cruise terminal at Port Vell. Drop bags, check in, and complete the safety drill. If boarding late afternoon (common), snack at La Boqueria’s El Quim de la Boqueria (counter seating; baby squid with fried eggs) or La Paradeta (choose‑your‑own seafood, cooked to order).
Evening: Sail‑away from the Barcelona skyline. Onboard, toast with cava, then plan a Gaudí day for a future visit: the Sagrada Família (timed entry ~€26–€33) and Casa Batlló’s color‑washed facade. Overnight sail to Marseille (~12 hours; ~210 nautical miles).
Day 2: Marseille, France
Morning: Shuttle or taxi to Vieux‑Port. Walk Le Panier’s pastel lanes to MuCEM and Fort Saint‑Jean, where bridges link galleries and ramparts with harbor views. Coffee with a sea breeze at Café de l’Abbaye or a specialty pour‑over at Deep Coffee.
Afternoon: Lunch on bouillabaisse at Chez Fonfon in Vallon des Auffes (reserve; classic rockfish stew served with rouille and croutons). Then ride up to Basilique Notre‑Dame de la Garde for a sweeping panorama; detour to Cours Julien for street art and a Provençal soap shop.
Evening: Golden‑hour photos in Vallon des Auffes; splurge on seafood at L’Épuisette (Michelin‑starred, on the water) or choose La Mercerie for a creative, seasonal neo‑bistro menu. Return to port. Overnight sail to Livorno (~13–14 hours; ~230 nautical miles).
Day 3: Livorno to Florence (or Pisa)
Morning: From Livorno Centrale, take a regional train to Firenze S.M.N. (~1h20; ~€10–€14; check Omio). Espresso at Ditta Artigianale, then the Duomo complex—climb Brunelleschi’s dome for city‑wide views if you have timed entry.
Afternoon: Lunch at Trattoria Mario (tuscan soups, bistecca; lunch‑only) or Da Nerbone in Mercato Centrale (lampredotto sandwiches and ribollita). For art, choose one: Uffizi (Botticelli’s Birth of Venus) or Accademia (Michelangelo’s David). Gelato at Gelateria dei Neri before heading back. Alternative: Pisa’s Leaning Tower is ~20–25 minutes from Livorno by train (~€3–€5); book tower climb slots ahead.
Evening: Back in Livorno, try a local “ponce” (rum‑spiked coffee) at historic Bar Civili before reboarding. Overnight sail to Civitavecchia (~6–8 hours; ~110 nautical miles).
Day 4: Rome in a Day (via Civitavecchia)
Morning: Walk or shuttle to Civitavecchia station; take the regional train to Roma S. Pietro or Termini (~60–75 min; ~€5–€10; see Omio). Do the Vatican first: Vatican Museums and Sistine Chapel (time slot strongly advised), then St. Peter’s Basilica (dress code enforced).
Afternoon: Cross the Tiber to Trastevere for lunch—Da Enzo al 29 (carbonara, artichokes; book or arrive early), or Trapizzino for handheld Roman classics in pizza cones. Metro to the Colosseum and Roman Forum (reserve a timed ticket). Espresso at Sant’Eustachio or gelato at Giolitti near the Pantheon.
Evening: Walk Piazza Navona to the Trevi Fountain (coin toss for good luck), then dinner in Testaccio at Flavio al Velavevodetto (pasta amatriciana in an ancient amphora‑walled dining room) or Roscioli Salumeria con Cucina for cacio e pepe with a deep wine list. Train back to Civitavecchia; overnight sail to Naples (~7–8 hours; ~120 nautical miles).
Day 5: Naples & Pompeii
Morning: Cappuccino at Gran Caffè Gambrinus (belle‑époque icon), then Circumvesuviana train to Pompei Scavi (~40 min; ~€3–€4). Explore houses, baths, frescoes, and the forum; plan 2–3 hours. Entry is ~€19; hats and water recommended.
Afternoon: Back in Naples, pizza pilgrimage: L’Antica Pizzeria da Michele (two choices done perfectly) or Gino e Totò Sorbillo (creative pies; expect a queue). Continue with Napoli Sotterranea (Underground Naples) to see ancient tunnels beneath the historic center. Snack stop at Sfogliatelle Attanasio for still‑warm riccia or frolla.
Evening: Sunset along the Lungomare to Castel dell’Ovo; dinner at Starita a Materdei (since 1901; try the montanara) or Mimi alla Ferrovia (classic Neapolitan trattoria). Overnight sail toward Spain; relaxing at sea tomorrow (~20–22 hours; long passage).
Day 6: A Day at Sea
Morning: Watch sunrise from the promenade, then join a stretch or yoga class. Enjoy a leisurely breakfast and an enrichment lecture—many ships offer talks on Mediterranean history, art, or wine.
Afternoon: Pool time or a cooking demo (learn paella or pesto). Consider a guided wine tasting or a spa treatment. Browse the art collection on board and take a bridge tour if offered.
Evening: Dress up for the show, then linger over a multi‑course dinner. Cap the night with live music in the lounge and stargazing on deck—Mediterranean skies can be crystal‑clear at sea.
Day 7: Barcelona Disembarkation
Morning: Disembark and store luggage if your flight is later. Breakfast at Federal Café Gòtic (Australian‑style coffee, wholesome plates) or El Quim de la Boqueria if you missed it earlier. Walk the Gothic Quarter to Plaça del Rei and the cathedral cloister with its resident geese.
Afternoon: If time allows, ride the Montjuïc cable car for aerial city views or relax in Parc de la Ciutadella. Taxi to BCN airport (~25–35 minutes; ~€30–€40 depending on traffic). For flights and trains, compare options on Omio (Flights) and Omio (Trains).
Evening: Departure day. If overnighting, choose stays via VRBO Barcelona or Hotels.com Barcelona, ideally in Eixample or El Born.
How to Get Around (Quick Reference)
- Port shuttles & taxis: Easiest for Marseille’s terminals and Civitavecchia port gate.
- Trains: Use Omio (Trains) to check schedules/fares for Livorno–Florence/Pisa, Civitavecchia–Rome, and Naples regionals.
- Ferries: For optional day boats (e.g., Capri from Naples), see Omio (Ferries).
- Flights: For pre/post cruise travel to Barcelona or from Spain, compare on Omio (Flights).
Eating & Drinking (Port Favorites)
- Barcelona: Cal Pep (counter tapas, seafood), El Xampanyet (anchovies, cava), Dr. Stravinsky (inventive cocktails).
- Marseille: Chez Fonfon (bouillabaisse), L’Épuisette (sea views, fine dining), La Mercerie (seasonal plates), pastis for aperitif.
- Florence/Pisa: Trattoria Mario (Tuscan classics), Da Nerbone (market fare), Gelateria dei Neri (top gelato), Caffè Gilli (historic café).
- Rome: Roscioli Salumeria (cured meats, pasta), Flavio al Velavevodetto (Roman pastas), Sant’Eustachio (espresso), Giolitti (gelato institution).
- Naples: Da Michele or Sorbillo (pizza canon), Starita (historic pizzeria), Sfogliatelle Attanasio (pastry), espresso standing at the bar.
In a single week, this Western Mediterranean cruise stitches together art capitals, ancient ruins, and culinary traditions that defined Europe. With smart timing, great food stops, and sea‑day downtime, you’ll step off the ship full of stories—and ready to plan your next voyage.

