19-Day Adventure Through the American Southwest: From Los Angeles to San Francisco

Embark on a 19-day journey through the stunning landscapes and vibrant cities of the American Southwest, exploring iconic national parks and bustling urban centers.

Welcome to an unforgettable 19-day journey through the American Southwest, a region renowned for its breathtaking landscapes and vibrant cities. This itinerary will guide you through iconic destinations, from the bustling streets of Los Angeles to the serene beauty of Yosemite National Park. Along the way, you'll explore the majestic Grand Canyon, the unique rock formations of Arches National Park, and the vibrant nightlife of Las Vegas.


Our adventure begins in Los Angeles, a city known for its entertainment industry and diverse cultural scene. From there, we'll travel to Palm Springs, a desert oasis famous for its mid-century modern architecture and stunning mountain views. As we continue our journey, we'll visit the awe-inspiring Grand Canyon, the red rock wonders of Moab, and the mystical Antelope Canyon.

Throughout this trip, you'll have the opportunity to engage in a variety of activities, from hiking in national parks to exploring vibrant cityscapes. Whether you're a nature enthusiast or a city explorer, this itinerary offers something for everyone. So pack your bags and get ready for an adventure of a lifetime!

Los Angeles

Days 1-3: Exploring the City of Angels

Start your journey in Los Angeles, a city that needs no introduction. Known for its iconic Hollywood sign, beautiful beaches, and diverse neighborhoods, LA offers a plethora of activities for every traveler. Begin your day with a visit to the Griffith Observatory for panoramic views of the city and the Hollywood sign. Don't miss a stroll along the Hollywood Walk of Fame, where you can spot the stars of your favorite celebrities.

For accommodations, consider staying at a cozy VRBO in the heart of the city or a comfortable hotel via Hotels.com. For breakfast, head to The Griddle Cafe for their famous pancakes, and for dinner, try the authentic Mexican cuisine at Guelaguetza.

Travel to Palm Springs via a scenic 2-hour drive. For car rentals, check out Trip.com for the best deals.


Palm Springs

Days 4-5: Desert Oasis and Mid-Century Marvels

Welcome to Palm Springs, a desert paradise known for its hot springs, stylish hotels, and golf courses. Explore the Palm Springs Aerial Tramway for breathtaking views of the Coachella Valley. For a touch of culture, visit the Palm Springs Art Museum, which houses an impressive collection of contemporary art.

Stay at a chic mid-century modern home via VRBO or a boutique hotel through Hotels.com. For dining, try Workshop Kitchen + Bar for farm-to-table cuisine or indulge in a classic steak at LG's Prime Steakhouse.

Continue your journey with a 4-hour drive to the Grand Canyon, a natural wonder that will leave you speechless.

Grand Canyon

Days 6-7: Witnessing Nature's Majesty

The Grand Canyon is a must-see destination, offering stunning vistas and endless opportunities for exploration. Spend your days hiking along the South Rim, where you can take in the breathtaking views of the canyon's vast expanse. For a unique experience, consider a guided tour to learn about the geology and history of this natural wonder.

Stay at a rustic lodge within the park or a nearby hotel via Hotels.com. For dining, enjoy a meal at the historic El Tovar Dining Room, offering classic American cuisine with a view.


Next, head to Moab, Utah, a gateway to some of the most stunning national parks in the country.

Moab and Arches National Park

Days 8-10: Red Rock Wonders

Moab is a haven for outdoor enthusiasts, offering easy access to Arches National Park and Canyonlands National Park. Spend your days hiking among the park's famous red rock formations, such as Delicate Arch and Landscape Arch. For a thrilling adventure, consider a guided jeep tour through the rugged terrain.

Stay at a cozy cabin or a comfortable hotel via Hotels.com. For dining, try the local favorite, Moab Brewery, for craft beers and hearty pub fare.

Continue your journey with a scenic drive to Page, Arizona, home to the stunning Antelope Canyon.

Page and Antelope Canyon

Days 11-12: Mystical Canyons and Lake Views

Page is a small town with big attractions, including the world-famous Antelope Canyon. Join a guided tour to explore the canyon's narrow passageways and capture the mesmerizing light beams that illuminate the sandstone walls. Don't miss a visit to Horseshoe Bend for a breathtaking view of the Colorado River.


Stay at a comfortable hotel via Hotels.com. For dining, enjoy a meal at Big John's Texas BBQ, known for its mouthwatering smoked meats.

Next, head to Las Vegas, the entertainment capital of the world, for a change of pace.

Las Vegas

Days 13-14: The Entertainment Capital

Las Vegas is a city that never sleeps, offering endless entertainment options, from world-class shows to vibrant nightlife. Spend your days exploring the famous Las Vegas Strip, where you can visit iconic casinos and enjoy spectacular performances. For a unique experience, take a helicopter tour over the city for a bird's-eye view of the dazzling lights.

Stay at a luxurious hotel on the Strip via Hotels.com. For dining, indulge in a gourmet meal at Gordon Ramsay Steak or enjoy a buffet at the Bellagio.

Continue your journey with a drive to Bryce Canyon National Park, known for its unique rock formations.


Bryce Canyon and Zion National Park

Days 15-16: Hoodoos and Hiking Trails

Bryce Canyon National Park is famous for its hoodoos, tall, thin spires of rock that create a surreal landscape. Spend your days hiking along the park's scenic trails, such as the Queen's Garden and Navajo Loop. For a different perspective, consider a horseback ride through the canyon.

Stay at a cozy lodge near the park or a nearby hotel via Hotels.com. For dining, try the local favorite, Bryce Canyon Pines Restaurant, for hearty American fare.

Next, head to Zion National Park, where you can explore its stunning canyons and towering cliffs.

Death Valley and Mammoth Lakes

Days 17-18: Extreme Landscapes and Alpine Beauty

Death Valley is a land of extremes, known for its scorching temperatures and unique landscapes. Visit Badwater Basin, the lowest point in North America, and explore the colorful Artist's Palette. For a change of scenery, head to Mammoth Lakes, a mountain town known for its outdoor activities and stunning alpine views.

Stay at a cozy cabin or a comfortable hotel via Hotels.com. For dining, try the local favorite, The Stove, for hearty breakfast options, or enjoy a meal at Mammoth Brewing Company for craft beers and pub fare.


Conclude your journey with a visit to Yosemite National Park, a UNESCO World Heritage Site known for its stunning natural beauty.

Yosemite National Park and San Francisco

Day 19: Natural Wonders and City Lights

Yosemite National Park is a must-visit destination, offering breathtaking views of granite cliffs, waterfalls, and giant sequoias. Spend your day exploring the park's iconic sites, such as El Capitan and Half Dome. For a unique experience, consider a guided tour to learn about the park's history and geology.

Stay at a rustic lodge within the park or a nearby hotel via Hotels.com. For dining, enjoy a meal at the historic Ahwahnee Dining Room, offering classic American cuisine with a view.

End your journey in San Francisco, a city known for its iconic landmarks and vibrant culture. Explore the Golden Gate Bridge, Alcatraz Island, and the bustling Fisherman's Wharf before heading home.

This 19-day adventure through the American Southwest offers a perfect blend of natural wonders and vibrant cityscapes. From the stunning landscapes of the Grand Canyon and Yosemite to the bustling streets of Los Angeles and San Francisco, this itinerary promises an unforgettable journey filled with adventure and discovery.


Ready to book your trip?

Search Hotels
Search Homes

Traveling somewhere else?

Generate a custom itinerary